1. Eli Lilly's Mounjaro (tirzepatide) met its co-primary and all secondary weight-loss endpoints in the Phase III SURMOUNT-2 study.
3. Participants taking the 10-mg dose of Mounjaro experienced a 13.4% average reduction in body weight, while the 15-mg dose led to a 15.7% average weight loss.
5. The study was randomized, double-blinded, and placebo-controlled, enrolling 938 participants from various countries.
6. Mounjaro's side effects were mostly mild or moderate, with nausea, diarrhea, and vomiting being the most common adverse events.
8. The FDA granted Mounjaro Fast Track designation in October 2022 for the treatment of adults with obesity or overweight and related comorbidities.
9. Lilly has recently posted a Phase IIIb study to compare Mounjaro against Wegovy in obese or overweight participants without T2D.