Humira Sales Down 25% as AbbVie Cuts Two Programs

BIOMARKER

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1. AbbVie's Humira sales have fallen by more than 25% due to the introduction of biosimilars.

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2. The first Humira biosimilar, Amgen's Amjevita, hit the U.S. market on January 31, 2023.

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3. Despite the decline, AbbVie is managing the situation well, according to outgoing CEO Rick Gonzalez.

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4. Eight other biosimilars have been approved by the FDA, and two more are currently under review.

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5. AbbVie is focusing on its other immunology drugs, Rinvoq and Skyrizi, which are expected to generate over $27 billion in annual revenue by 2027.

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6. Rinvoq and Skyrizi missed revenue estimates by $127 million in the first quarter but are on track to contribute over $11 billion in combined sales this year.

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7. Botox sales exceeded Wall Street estimates, with cosmetic applications surpassing $659 million, and therapeutic use increasing 17% to $719 million.

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8. AbbVie has announced the discontinuation of two early-stage pipeline programs: one for cystic fibrosis and the other for polymyalgia rheumatica and Crohn's disease.

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9. Skyrizi is already approved to treat Crohn’s disease, and Rinvoq, the first oral Janus kinase (JAK) inhibitor for Crohn’s, is awaiting U.S. approval after being greenlit in the EU.

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10. After leading the company for ten years, CEO Rick Gonzalez plans to step down following the transition for Humira biosimilars, potentially taking on the role of executive chairman during the transition period.

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