Ma2 (Ta) is most commonly occurring amongst the Ma family (Ma1, Ma2 & Ma3) and targets 41.5 kDa antigen confined to the central nervous system.

Ma2 is associated with brainstem encephalitis and limbic encephalitis.

Germ-cell neoplasm of the testis occurs in about 80% of the cases.

Image: Purkinje cells, Ma2 binds to the nuclei and nucleoli of all neurones in the CNS.