:root{
  --paper:#F4F5F2; --card:#FFFFFF; --ink:#16211E; --ink-2:#4C574F;
  --ink-3:#77837A; --line:#E3E6DF; --line-2:#EDEFEA;
  --accent:#0C6B57; --accent-2:#0A5A49; --accent-soft:#E7F0EC;
  --est-bg:#E4EFE7; --est-tx:#1C6B47;
  --emg-bg:#F7EEDA; --emg-tx:#8A6014;
  --hl:#FBEFC6;
  --sans:'Inter',system-ui,-apple-system,'Segoe UI',Roboto,sans-serif;
  --serif:'Newsreader',Georgia,'Times New Roman',serif;
  --mono:'IBM Plex Mono',ui-monospace,'SFMono-Regular',Menlo,monospace;
  --shadow:0 1px 2px rgba(22,33,30,.04),0 8px 24px -12px rgba(22,33,30,.12);
  --maxw:1220px;
}
*{box-sizing:border-box}
html{-webkit-text-size-adjust:100%}
body{
  margin:0; background:var(--paper); color:var(--ink);
  font-family:var(--sans); font-size:15px; line-height:1.5;
  -webkit-font-smoothing:antialiased; text-rendering:optimizeLegibility;
}
a{color:inherit;text-decoration:none}
::selection{background:var(--hl)}
.wrap{max-width:var(--maxw);margin:0 auto;padding:0 24px}

/* ---------- Masthead ---------- */
.mast{
  position:sticky;top:0;z-index:40;background:rgba(244,245,242,.86);
  backdrop-filter:saturate(1.4) blur(10px);border-bottom:1px solid var(--line);
}
.mast-in{display:flex;align-items:center;gap:20px;padding:16px 24px;max-width:var(--maxw);margin:0 auto;flex-wrap:wrap}
.brand{display:flex;flex-direction:column;gap:2px;min-width:0;color:inherit;text-decoration:none}
.brand:hover h1{color:var(--accent)}
.brand .eyebrow{font-family:var(--mono);font-size:10.5px;letter-spacing:.16em;text-transform:uppercase;color:var(--accent);font-weight:500}
.brand h1{font-family:var(--serif);font-weight:500;font-size:23px;line-height:1;margin:0;letter-spacing:-.01em}
.controls{display:flex;align-items:center;gap:12px;margin-left:auto;flex-wrap:wrap}
.search{position:relative;flex:1 1 320px;min-width:230px}
.search svg{position:absolute;left:13px;top:50%;transform:translateY(-50%);width:16px;height:16px;color:var(--ink-3);pointer-events:none}
.search input{
  width:100%;font-family:var(--sans);font-size:14.5px;color:var(--ink);
  background:var(--card);border:1px solid var(--line);border-radius:9px;
  padding:10px 34px 10px 38px;outline:none;transition:border-color .15s,box-shadow .15s;
}
.search input::placeholder{color:var(--ink-3)}
.search input:focus{border-color:var(--accent);box-shadow:0 0 0 3px var(--accent-soft)}
.search .clr{position:absolute;right:8px;top:50%;transform:translateY(-50%);border:0;background:none;color:var(--ink-3);cursor:pointer;padding:6px;border-radius:6px;display:none;line-height:0}
.search .clr:hover{color:var(--ink);background:var(--line-2)}
.search.has-val .clr{display:block}
.segmented{display:inline-flex;background:var(--line-2);border:1px solid var(--line);border-radius:9px;padding:3px}
.segmented button{
  font-family:var(--mono);font-size:11px;letter-spacing:.06em;text-transform:uppercase;
  border:0;background:none;color:var(--ink-2);padding:6px 11px;border-radius:6px;cursor:pointer;font-weight:500;transition:.12s;
}
.segmented button[aria-pressed="true"]{background:var(--card);color:var(--ink);box-shadow:0 1px 2px rgba(22,33,30,.08)}

/* ---------- Directory ---------- */
.dir-head{display:flex;align-items:baseline;justify-content:space-between;gap:16px;padding:26px 0 14px;flex-wrap:wrap}
.dir-meta{display:flex;align-items:center;gap:16px;flex-wrap:wrap}
.dir-head .count{font-family:var(--mono);font-size:12.5px;color:var(--ink-2);letter-spacing:.02em}
.dir-head .count b{color:var(--ink);font-weight:600}
.dir-head .lede{font-size:14px;color:var(--ink-2);max-width:52ch}
.tablecard{background:var(--card);border:1px solid var(--line);border-radius:14px;box-shadow:var(--shadow);overflow:hidden;margin-bottom:40px;position:relative}
.tscroll{overflow-x:auto}
table{border-collapse:collapse;width:100%;min-width:1000px;table-layout:fixed}
td .chip{font-size:9.5px;padding:3px 7px;letter-spacing:.02em;gap:4px;max-width:100%}
.c-status{padding-left:12px !important;padding-right:8px !important}
thead th{
  position:sticky;top:0;background:var(--card);z-index:2;vertical-align:bottom;
  font-family:var(--mono);font-size:10px;letter-spacing:.08em;text-transform:uppercase;
  color:var(--ink-3);font-weight:600;text-align:left;padding:14px 14px;border-bottom:1px solid var(--line);
  white-space:normal;cursor:pointer;user-select:none;transition:color .12s;line-height:1.3;
}
thead th:hover{color:var(--ink)}
thead th .sortdot{display:inline-block;margin-left:5px;opacity:0;transition:opacity .12s;font-size:9px}
thead th[aria-sort]:not([aria-sort="none"]) .sortdot{opacity:1;color:var(--accent)}
thead th[aria-sort="descending"] .sortdot{transform:rotate(180deg)}
tbody tr{border-bottom:1px solid var(--line-2);cursor:pointer;transition:background .1s}
tbody tr:last-child{border-bottom:0}
tbody tr:hover{background:#F8FAF7}
tbody tr:focus-visible{outline:2px solid var(--accent);outline-offset:-2px}
td{padding:14px 14px;vertical-align:top;color:var(--ink-2);font-size:13px}
td.c-name{position:sticky;left:0;background:var(--card);z-index:1}
tbody tr:hover td.c-name{background:#F8FAF7}
.bmk{font-family:var(--mono);font-weight:600;font-size:13.5px;color:var(--ink);letter-spacing:-.01em;line-height:1.3;display:inline-flex;align-items:baseline;gap:6px;word-break:break-word}
tbody tr:hover .bmk{color:var(--accent)}
.bmk .arw{opacity:0;transition:.12s;color:var(--accent)}
tbody tr:hover .bmk .arw{opacity:1;transform:translateX(1px)}
.clamp{display:-webkit-box;-webkit-line-clamp:2;-webkit-box-orient:vertical;overflow:hidden}
.clamp1{display:-webkit-box;-webkit-line-clamp:1;-webkit-box-orient:vertical;overflow:hidden}
.muted-mono{font-family:var(--mono);font-size:12px;color:var(--ink-2)}
.col-aliases{max-width:150px}
.col-diseases{max-width:230px}
.col-desc{max-width:280px}
.col-sig{max-width:280px}
.col-method{max-width:180px}
.col-spec{max-width:170px}
mark{background:var(--hl);color:inherit;border-radius:2px;padding:0 1px}

/* status chip */
.chip{display:inline-flex;align-items:center;gap:5px;font-family:var(--mono);font-size:10.5px;font-weight:600;letter-spacing:.05em;text-transform:uppercase;padding:4px 9px;border-radius:999px;white-space:nowrap}
.chip .dot{width:5px;height:5px;border-radius:999px;background:currentColor}
.chip.established{background:var(--est-bg);color:var(--est-tx)}
.chip.emerging{background:var(--emg-bg);color:var(--emg-tx)}

.empty{padding:64px 24px;text-align:center;color:var(--ink-2)}
.empty h3{font-family:var(--serif);font-weight:500;font-size:20px;color:var(--ink);margin:0 0 6px}
.empty p{margin:0 0 4px;font-size:14px}
.empty button{margin-top:14px;font-family:var(--mono);font-size:12px;border:1px solid var(--line);background:var(--card);color:var(--ink);padding:8px 14px;border-radius:8px;cursor:pointer}
.empty button:hover{border-color:var(--accent);color:var(--accent)}

/* ---------- Card layout (small screens) ---------- */
.msort{display:none;align-items:center;gap:8px}
.msort label{font-family:var(--mono);font-size:10px;letter-spacing:.1em;text-transform:uppercase;color:var(--ink-3);display:inline-flex;align-items:center;gap:7px}
.msort select{font-family:var(--sans);font-size:13px;color:var(--ink);background:var(--card);border:1px solid var(--line);border-radius:8px;padding:7px 9px;cursor:pointer;outline:none}
.msort select:focus{border-color:var(--accent);box-shadow:0 0 0 3px var(--accent-soft)}
.msort .dir{border:1px solid var(--line);background:var(--card);color:var(--ink-2);width:34px;height:34px;border-radius:8px;cursor:pointer;font-size:12px;line-height:1;display:inline-flex;align-items:center;justify-content:center;flex:none}
.msort .dir:hover{border-color:var(--accent);color:var(--accent)}
.bcards{display:grid;gap:13px;grid-template-columns:repeat(auto-fill,minmax(340px,1fr));margin-bottom:40px}
.bcard{display:block;background:var(--card);border:1px solid var(--line);border-radius:14px;box-shadow:var(--shadow);padding:16px 17px;text-align:left;transition:border-color .12s,box-shadow .12s;-webkit-tap-highlight-color:transparent}
.bcard:hover,.bcard:focus-visible{border-color:#CFE2DA;box-shadow:0 2px 4px rgba(22,33,30,.05),0 14px 30px -14px rgba(12,107,87,.28);outline:none}
.bcard:active{transform:scale(.995)}
.bcard-top{display:flex;align-items:center;gap:10px;justify-content:space-between}
.bcard-name{font-family:var(--mono);font-weight:600;font-size:16px;color:var(--ink);letter-spacing:-.01em;line-height:1.25;word-break:break-word}
.bcard:hover .bcard-name{color:var(--accent)}
.bcard-aliases{font-family:var(--mono);font-size:12px;color:var(--ink-2);margin-top:7px;line-height:1.45}
.bcard-facts{margin:13px 0 0;padding:13px 0 0;border-top:1px solid var(--line-2);display:grid;gap:11px}
.bcard-facts .f .k{font-family:var(--mono);font-size:9.5px;letter-spacing:.12em;text-transform:uppercase;color:var(--ink-3);margin-bottom:3px}
.bcard-facts .f .val{font-size:13.5px;line-height:1.5;color:var(--ink)}
.bcard-facts .f .val.mono{font-family:var(--mono);font-size:12.5px;color:var(--ink-2)}
.bcard-facts .pair{display:grid;grid-template-columns:1fr 1fr;gap:11px}
@media(max-width:400px){.bcard-facts .pair{grid-template-columns:1fr}}

/* ---------- Detail ---------- */
.detail{padding:22px 0 72px;animation:fade .28s ease}
@keyframes fade{from{opacity:0;transform:translateY(6px)}to{opacity:1;transform:none}}
.back{display:inline-flex;align-items:center;gap:7px;font-family:var(--mono);font-size:12px;letter-spacing:.04em;color:var(--ink-2);padding:7px 0;margin-bottom:8px}
.back:hover{color:var(--accent)}
.back svg{width:14px;height:14px}
/* Index: same top spacing as detail pages; avoid stacking with dir-head padding */
.directory .dir-head{padding-top:8px}
.dhead{border-bottom:1px solid var(--line);padding-bottom:22px;margin-bottom:26px}
.dhead .toprow{display:flex;align-items:center;gap:12px;flex-wrap:wrap;margin-bottom:12px}
.dhead h2{font-family:var(--mono);font-weight:600;font-size:clamp(28px,5vw,40px);letter-spacing:-.02em;margin:0;line-height:1}
.dhead .subline{font-family:var(--serif);font-size:19px;line-height:1.45;color:var(--ink);font-weight:400;max-width:74ch;margin:0}
.aliases-row{display:flex;flex-wrap:wrap;align-items:center;gap:8px;margin-top:16px}
.aliases-row .lbl{font-family:var(--mono);font-size:10px;letter-spacing:.14em;text-transform:uppercase;color:var(--ink-3)}
.tag{font-family:var(--mono);font-size:12px;color:var(--ink-2);background:var(--line-2);border:1px solid var(--line);padding:3px 9px;border-radius:6px}

.dgrid{display:grid;grid-template-columns:minmax(0,1fr) 320px;gap:40px;align-items:start}
.sec{margin-bottom:30px}
.sec .eyebrow{font-family:var(--mono);font-size:10.5px;letter-spacing:.14em;text-transform:uppercase;color:var(--accent);font-weight:600;display:flex;align-items:center;gap:9px;margin-bottom:11px}
.sec .eyebrow::after{content:"";flex:1;height:1px;background:var(--line)}
.sec p{margin:0;font-size:15.5px;line-height:1.62;color:var(--ink)}

.plain{background:var(--accent-soft);border:1px solid #CFE2DA;border-radius:14px;padding:20px 22px;margin-bottom:30px}
.plain .eyebrow{font-family:var(--mono);font-size:10.5px;letter-spacing:.14em;text-transform:uppercase;color:var(--accent-2);font-weight:600;margin-bottom:9px;display:flex;align-items:center;gap:8px}
.plain p{margin:0;font-size:15.5px;line-height:1.62;color:#123f34}

/* sidebar card */
.aside{position:sticky;top:88px;display:flex;flex-direction:column;gap:16px}
.factcard{background:var(--card);border:1px solid var(--line);border-radius:14px;box-shadow:var(--shadow);overflow:hidden}
.factcard .fc-head{font-family:var(--mono);font-size:10.5px;letter-spacing:.14em;text-transform:uppercase;color:var(--ink-3);font-weight:600;padding:15px 18px 0}
.fact{padding:14px 18px;border-bottom:1px solid var(--line-2)}
.fact:last-child{border-bottom:0}
.fact .k{font-family:var(--mono);font-size:10px;letter-spacing:.1em;text-transform:uppercase;color:var(--ink-3);margin-bottom:5px}
.fact .v{font-size:13.5px;line-height:1.5;color:var(--ink)}
.fact .v.mono{font-family:var(--mono);font-size:12.5px}
.disease-chips{display:flex;flex-wrap:wrap;gap:6px}
.disease-chips .dc{font-size:12px;background:var(--accent-soft);color:var(--accent-2);border-radius:6px;padding:3px 8px;line-height:1.35}

/* references */
.refs{border-top:1px solid var(--line);padding-top:24px;margin-top:8px}
.refs .eyebrow{font-family:var(--mono);font-size:10.5px;letter-spacing:.14em;text-transform:uppercase;color:var(--ink-3);font-weight:600;margin-bottom:14px}
.refs ol{list-style:none;counter-reset:r;margin:0;padding:0;display:grid;gap:12px}
.refs li{counter-increment:r;position:relative;padding-left:34px;font-size:13.5px;line-height:1.55;color:var(--ink-2);max-width:88ch}
.refs li::before{content:counter(r,decimal-leading-zero);position:absolute;left:0;top:1px;font-family:var(--mono);font-size:11px;color:var(--accent);font-weight:600}

.foot{border-top:1px solid var(--line);margin-top:48px}
.foot .wrap{padding:22px 24px;display:flex;justify-content:space-between;gap:16px;flex-wrap:wrap;font-family:var(--mono);font-size:11px;color:var(--ink-3);letter-spacing:.03em}

/* responsive */
@media(max-width:1080px){
  .msort{display:flex}
}
@media(max-width:900px){
  .dgrid{grid-template-columns:1fr;gap:8px}
  .aside{position:static;order:-1;margin-bottom:8px}
}
@media(max-width:640px){
  .wrap,.mast-in,.foot .wrap{padding-left:16px;padding-right:16px}
  .mast-in{gap:12px}
  .brand h1{font-size:20px}
  .controls{width:100%;margin-left:0}
  .search{flex:1 1 100%}
  td,thead th{padding:12px 14px}
}
@media(prefers-reduced-motion:reduce){*{animation:none!important;transition:none!important}}