CV2 (CRMP5) antibody binds to cytoplasm and cell processes of a subpopulation of oligodendrocytes in the white matter and targets 66 kDa protein known as CRMP5.

It is most commonly found in association with small cell lung carcinoma at a frequency of 77%.
CV2 autoimmune response can be found in cerebellar ataxia, encephalomyelitis, limbic encephalitis, sensory and sensorimotor neuropathy, autonomic neuropathy, and chorea.

Image: Primate cerebellar white matter showing CV2 staining.