Rodent stomach – no staining seen		Rodent live stained with LKM antibodies	Rodent kidney – proximal tubules stained
Stomach		Liver	Kidney tubules
Parietal cells	Chief cells	Hepatocytes	Proximal	Distal
–	–	+++	++	–
In contrast to anti-mitochondrial antibody, LKM does not stain rodent stomach.		Homogenous staining of rodent liver with LKM antibody. Nuclei are counterstained red with ethidium bromide.	Specific staining is seen in the cytoplasm of proximal renal tubules but not in distal.
Antigen: Cytochrome P450 Disease: LKM antibodies are strongly associated with type 2 autoimmune hepatitis.